Frequency-Dependent Multi-Well Cardiotoxicity Screening Enabled by Optogenetic Stimulation
نویسندگان
چکیده
منابع مشابه
Frequency-Dependent Multi-Well Cardiotoxicity Screening Enabled by Optogenetic Stimulation
Side effects on cardiac ion channels causing lethal arrhythmias are one major reason for drug withdrawals from the market. Field potential (FP) recording from cardiomyocytes, is a well-suited tool to assess such cardiotoxic effects of drug candidates in preclinical drug development, but it is currently limited to the spontaneous beating of the cardiomyocytes and manual analysis. Herein, we pres...
متن کاملHigh-frequency hippocampal oscillations activated by optogenetic stimulation of transplanted human ESC-derived neurons.
After transplantation, individual stem cell-derived neurons can functionally integrate into the host CNS; however, evidence that neurons derived from transplanted human embryonic stem cells (hESCs) can drive endogenous neuronal network activity in CNS tissue is still lacking. Here, using multielectrode array recordings, we report activation of high-frequency oscillations in the β and γ ranges (...
متن کاملBrief Communications High-Frequency Hippocampal Oscillations Activated by Optogenetic Stimulation of Transplanted Human ESC-Derived Neurons
Juan C. Piña-Crespo,1* Maria Talantova,1* Eun-Gyung Cho,1* Walid Soussou,1 Nima Dolatabadi,1 Scott D. Ryan,1 Rajesh Ambasudhan,1 Scott McKercher,1 Karl Deisseroth,2 and Stuart A. Lipton1 1Del E. Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, and 2Department of Psychiatry and Behavioral Sciences, Stanford Unive...
متن کاملHighlight report: Cardiotoxicity screening
have published a review about identification of cardiotoxic compounds by rapid screening methods (Li et al., 2015). Cardiotoxicity is one of the most frequent causes for withdrawal of drugs from the market and also during drug development (MacDonald and Robertson, 2009; Apostolakis et al., 2013; Li et al., 2015). Totally, 81 drugs have been taken from the market between 1990 and 2013 (Li et al....
متن کاملNMDA Receptor-Dependent Metaplasticity by High-Frequency Magnetic Stimulation
High-frequency magnetic stimulation (HFMS) can elicit N-methyl-D-aspartate (NMDA) receptor-dependent long-term potentiation (LTP) at Schaffer collateral-CA1 pyramidal cell synapses. Here, we investigated the priming effect of HFMS on the subsequent magnitude of electrically induced LTP in the CA1 region of rat hippocampal slices using field excitatory postsynaptic potential (fEPSP) recordings. ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2017
ISSN: 1422-0067
DOI: 10.3390/ijms18122634